Whole genome sequencing uncovers a novel IND-16 metallo-β-lactamase from an extensively drug-resistant Chryseobacterium indologenes strain J31
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Whole genome sequencing uncovers a novel IND-16 metallo-β-lactamase from an extensively drug-resistant Chryseobacterium indologenes strain J31
BACKGROUND Chryseobacterium indologenes is an emerging opportunistic pathogen in hospital-acquired infection, which is intrinsically resistant to most antimicrobial agents against gram-negative bacteria. In the purpose of extending our understanding of the resistance mechanism of C. indologenes, we sequenced and analyzed the genome of an extensively antibiotic resistant C. indologenes strain, i...
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*Corresponding author; mailing address: Jean-Denis Docquier, Dipartimento di Biologia Molecolare, Università di Siena, Policlinico “Le Scotte”, I-53100 Siena, Italy. Tel. 39 0577 233134; Fax: 39 0577 233870; e-mail: [email protected]. Copyright © 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.0...
متن کاملIdentification and characterization of a new metallo-beta-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes.
A new natural IND-type metallo-beta-lactamase variant, IND-5, was identified in a clinical isolate of Chryseobacterium indologenes. IND-5 shared 92.8% and 92.4% amino acid homology with IND-1 and IND-3, respectively. Purified enzyme (pI = 8.8, M(r) = 25,000) was able to hydrolyze penicillins, some narrow- and expanded-spectrum cephalosporins, and carbapenems but not monobactams.
متن کاملIdentification and Characterization of a New Metallo- -Lactamase, IND-5, from a Clinical Isolate of Chryseobacterium indologenes
Identification and Characterization of a New Metallo-Lactamase, IND-5, from a Clinical Isolate of Chryseobacterium indologenes Mariagrazia Perilli, Bibiana Caporale, Giuseppe Celenza, Cristina Pellegrini, Jean Denis Docquier, Marilina Mezzatesta, Gian Maria Rossolini, Stefania Stefani, and Gianfranco Amicosante* Dipartimento di Scienze e Tecnologie Biomediche, Università di L’Aquila, I-67100 L’...
متن کاملresistome analysis of Enterobacter cloacae CY01, an extensively drug-resistant strain producing VIM-1 metallo-β-lactamase from China.
Resistome analysis of clinical VIM-1-producing Enterobacter cloacae strain CY01 from China revealed the presence of multiple resistance determinants. Two resistance plasmids were identified in CY01. The pCY-VIM plasmid was 14 kb in size and possessed a replicase gene (repA), a gene cluster encoding the partitioning function (parABC), and a carbapenemase gene (blaVIM-1). Another 5.9-kb plasmid, ...
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ژورنال
عنوان ژورنال: Gut Pathogens
سال: 2016
ISSN: 1757-4749
DOI: 10.1186/s13099-016-0130-4